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Prof. Dr. Michael W. Linscheid
Michael W. Linscheid

Phone +49 (0)30 2093 7588
Fax +49 (0)30 2093 6985
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Department of Chemistry
Humboldt-Universität zu Berlin
Brook-Taylor-Str. 2
12489 Berlin-Adlershof

Administration Assistant:
Petra Esperling
Phone +49 (0)30 2093 7575

Analytical & Environmental Chemistry

Molecular sciences revolutionized biomedical research and triggered the development of the biotechnology industry. During the coming decades, the merging of quantitative sciences such as informatics, physics and chemistry  with biomedical research will trigger the next revolution that is to improve basic understanding of the complex processes in living systems as well as in human health care, since there is no doubt that small changes have great effects.
In this context the development of accurate analytical methods must be considered pivotal.
The understanding of biological processes will be impossible without information about the minute changes induced in cells by interactions of cell constituents with all sorts of endogenous and exogenous influences and disturbances.
In order to understand the role of biomolecules, the primary interest of the group is to elucidate molecular structures and to quantify their amount present in a sample.

We at the group of Applied Analytical and Environmental Chemistry are devoted to the analysis of biomolecules such as peptides, proteins, lipids and nucleic acids. We develop accurate and robust analytical procedures for the investigation of their biological role and to this end, chromatographic and electrophoretic separation techniques coupled to mass spectrometry are indispensable tools. Mass spectrometry has always been a key technology in life sciences and its importance is ever increasing.

Currently we conduct research in the following fields:

  • Quantitative Proteomics
In the field of proteomics, the focus moves from identification to quantification. We are developing techniques to enable relative and absolute quantification of peptides and proteins. With MeCAT (Metal Coded Affinity Tagging) technology, quantitative proteomics can exploit the advantages of element mass spectrometry, such as high sensitivity and absolute quantification.
  • Analysis and Quantification of modified DNA
The antitumor activity of numerous cytostatic drugs is predominantly based on the direct reaction of the substance with the DNA. To understand the mode of action of those drugs, elucidation of the key structures plays an important role. Based on these results, the next step is to quantify the formed products by means by elemental mass spectrometry.
  • Predatory Bacteria
Bdellovibrios are bacteria that hunt, invade and kill a variety of other bacteria. The unique lifestyle needs a specialised machinery for identifying suitable prey, attaching to it and entering the prey cell. We are especially interested in membrane constituents, such as membrane proteins and lipopolysaccharides and their role for the lifecycle of those unique predators.
  • Gas Phase Behaviour of natural and artificial Nucleic Acids
The fragmentation behaviour of oligonucleotides, such as DNA, RNA and PNA (peptide nucleic acids), under different excitation conditions (CID, IRMPD, ECD, etc.) is of special interest. The non-covalent interaction of complementary and non-complementary oligonucleotide double strands in the gas phase will be studied using high resolution mass spectrometry.
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